Search results for " Bupropion."
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The neurobiological bases for the pharmacotherapy of nicotine addiction.
2007
Nicotine, the major psychoactive agent present in tobacco, acts as a potent addictive drug both in humans and laboratory animals, whose locomotor activity is also stimulated. A large body of evidence indicates that the locomotor activation and the reinforcing effects of nicotine may be related to its stimulatory effects on the mesolimbic dopaminergic function. Thus, it is now well established that nicotine can increase in vivo DA outflow in the nucleus accumbens and the corpus striatum. The stimulatory effect of nicotine on DA release most probably results from its ability to excite the neuronal firing rate and to increase the bursting activity of DA neurons in the substantia nigra pars com…
Vareniclina. Un paso más en la lucha contra el tabaquismo
2007
Recientemente la Food and Drugs Administration ha aprobado Vareniclina, fármaco para la deshabituación tabáquica que presenta un novedoso mecanismo de acción, agonismo parcial de receptores nicotínicos de acetilcolina a4ß2.Hemos revisado la farmacología, eficacia y seguridad de Vareniclina y su utilidad en los procesos de deshabituación, usando como fuentes bibliográficas la base de datos MEDLINE , MD consults, American journal of Addictions y distintos manuales de referencia.De los tres ensayos clínicos publicados, dos de ellos, Jorenby y Gonzales comparan la eficacia y seguridad de Vareniclina 1mg/12h frente a Bupropion 150mg/12h y placebo, durante un periodo de 52 semanas, obteniéndose l…